Assay for Early Diagnosis of Anthrax Using Monoclonal Antibodies Against...
Anthrax is a serious infectious disease caused by bacteria known as Bacillus anthracis. Anthrax-contaminated spores can be found naturally in soil and they commonly affect domestic and wild animals...
View ArticleAntibodies for Rabies Post-exposure Prophylaxis or Antiviral Therapy of...
Lyssaviruses are single-stranded RNA viruses that cause rabies and rabies-like diseases in mammals. According to the World Health Organization, human rabies caused by the classical rabies virus...
View ArticleLicensing Availability: Methods of Diagnosing and Treating CHAPLE, A Newly...
This technology is directed towards a potential treatment for a new disease, CHAPLE (Complement Hyperactivation, Angiopathic thrombosis, and Protein-Losing Enteropathy), identified by NIAID...
View ArticleImmunoassays and Methods to Diagnose Syphilis by Immobilizing a Lipoidal...
Syphilis, a genital ulcerative disease caused by the bacterium Treponema pallidum, is associated with significant complications if left untreated. Syphilis rates in the United States have been...
View ArticleCardiolipin Modification for Immunoassay Detection of Syphilis
Syphilis is a sexually transmitted disease (STD) that remains a global health threat. Syphilis rates in the United States have also been increasing. Left untreated, syphilis infection can span decades...
View ArticleHigh-throughput assay for detection of rabies neutralizing antibodies
According to 2010-2014 World Health Organization (WHO) research, dog-transmitted human rabies was present or suspected in 150 countries and territories worldwide. Domestic dogs were the most common...
View ArticleMonoclonal Antibodies that Bind Zika Virus Envelope Protein for Zika...
Zika virus infection during pregnancy can cause microcephaly and other severe birth defects. The CDC Zika MAC-ELISA (IgM antibody capture enzyme-linked immunosorbent assay) currently used for diagnosis...
View ArticleMonoclonal Antibody to Detect the Antiretroviral Drug Emtricitabine – for HIV...
The U.S. Food and Drug Administration and World Health Organization (WHO) approved the antiretroviral drug emtricitabine (FTC)/ tenofovir disoproxil fumurate (TDF) combination for HIV pre-exposure...
View ArticleMonoclonal Antibodies that Neutralize Norovirus
Vaccines and therapies to prevent and treat Norovirus infections do not exist, despite the worldwide prevalence of Norovirus infections. Outbreaks of human gastroenteritis attributable to Norovirus...
View ArticleNeutralizing Monoclonal Antibodies to Botulinum Neurotoxin Type A
Two chimpanzee mAbs specifically reacted with light chain of the botulinum neurotoxin A and neutralize the toxin in the mouse model. They can be used for emergency prophylaxis and treatment of either...
View ArticleNovel One-Well Limiting-Antigen Avidity Enzyme Immunoassay to Detect Recent...
This CDC developed Limiting-Antigen avidity Enzyme Immunoassay (LAg-avidity-EIA) provides an easy way to measure increasing binding strength (avidity) of HIV antibodies as part of maturation HIV...
View ArticleStable Human Cell Lines Expressing Flavivirus Virus-Like Particles (VLPs) for...
Flaviviruses such as Zika virus, dengue virus, West Nile virus, yellow fever virus, and Japanese encephalitis virus cause widespread illness and death throughout the world. Typically, flaviviruses get...
View ArticleMonoclonal Antibodies Against Coxiella burnetii, the Cause of Q Fever for...
Coxiella burnetii (C. burnetii), the bacterium that causes Q fever, gets transmitted by inhalation and remains extremely stable in the environment. It has a very low infectious dose (very few bacteria...
View ArticleReducing Bloodstream Neutrophils as a Treatment for Lung Infection and...
During lung infection, bloodstream neutrophils (PMNs) responding to infection travel to the airspace lumen. Although successful arrival of microbicidal PMNs to the airspace is essential for host...
View ArticleMonoclonal Antibodies for Detection of Rabies Virus Antigen and Confirmatory...
According to the World Health Organization (WHO), rabies causes greater than 59,000 deaths every year in over 150 countries as of 2017. A rapid and reliable diagnostic test for rabies is critical for...
View ArticleMonoclonal Antibody that Detects a Subclass of Dog IgG—for Diagnostic and...
CDC and collaborating researchers have developed a new monoclonal antibody that recognizes canine IgG (likely IgG4 subclass). This anti-dog IgG reagent could be used to detect antibody reactions to a...
View ArticleDiagnostic Assay to Detect Group C Rotavirus in Humans and Animals—Monoclonal...
Rotaviruses cause severe gastroenteritis in humans and animals globally. Currently, there are eight known serogroups (A-H) of rotaviruses. Group C rotavirus (GpC RV) causes sporadic cases and outbreaks...
View ArticleHybridomas to Human Immunoglobulins for SARS-CoV-2 Diagnostics and Additional...
Immunoglobulins play a key role in the immune system. CDC has developed and tested hybridoma cell lines (monoclonal antibody (mAb) clones) for human IgG and other immunoglobulins. The mAbs generated...
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